Thursday, February 2, 2023
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Don’t ignore swollen breast lumps! Early detection of high-risk early-stage triple-negative breast cancer, new trends in treatment to prolong survival

Female friends, no matter how busy you are, you should pay more attention to breast health! Miss Xiaoyu is a full-time mother. In order to take care of two young children, she can only take a battle bath. On one day 5 years ago, with the help of her husband to take care of the children, she was able to take a leisurely bath, but suddenly touched her.

When I got a lump in the breast, the medical examination found “high-risk early-stage triple-negative breast cancer”. I was sad and crying for a while, but when I saw the sleeping face of the child, I decided to face the disease firmly, and under the doctor’s advice, I received the adjuvant immunotherapy combined with chemotherapy.

surgery and postoperative adjuvant therapy, so far no cancer recurrence has been found, which also proves that even in the face of highly malignant triple-negative breast cancer, there is still hope.

No equal treatment! Recognize the 2 major conditions of “high-risk early-stage triple-negative breast cancer”

Breast cancer ranks first in the incidence of cancer among women in China. According to the 2018 Cancer Registration Annual Report of the Ministry of Health and Welfare, there are about 15,000 new breast cancer patients in Taiwan every year.

Among all breast cancer types, triple-negative breast cancer accounts for about 10-15%. Liu Liangzhi, director of the Breast Medical Center of the Medical System of China Medical University, said that it was clinically found that a group of patients were prone to relapse earlier after chemotherapy, and treatment should not be treated equally.

Therefore, further research is required to identify the “high-risk early-stage triple-negative breast cancer” groups that are prone to relapse, and give them corresponding treatment strategies.

So-called triple-negative breast cancer is when three recipients are negative:

・Estrogen (ER)

・Progesterone (PR)

・Type II human epithelial growth receptor (HER2)

High-risk early-stage triple-negative breast cancer is defined as one of the following:

・The tumor is between 1-2 cm with lymphatic metastasis

・Tumor larger than 2 cm, regardless of lymphatic metastasis


In the past, most patients could only choose chemotherapy, but in recent years, with the development of immunotherapy drugs, if chemotherapy is combined with immunotherapy, there is a chance to increase the probability of “pathological complete remission” (pCR, that is, no cancer cells can be detected in surgical specimens). At the same time, it can reduce the risk of recurrence and pursue a longer survival time.

Immunotherapy can help! Opportunity to reduce recurrence and prolong survival of high-risk early-stage triple-negative breast cancer

Lin Jinyao, director of the Breast Medical Center of Taichung Tzu Chi Hospital, pointed out that compared with other breast cancer types, triple-negative breast cancer has a higher recurrence rate within 3 years of treatment.

Chances may be lower than with other types of breast cancer. Therefore, high-risk early-stage triple-negative breast cancer patients who receive advanced adjuvant therapy need to pursue tumor clearance to the point that they cannot be detected.

In addition, Director Liu Liangzhi said that event-free survival (EFS) and overall survival time are also key indicators to evaluate the treatment outcomes of high-risk early-stage triple-negative breast cancer.

International studies have found that patients with high-risk early-stage triple-negative breast cancer who receive preoperative adjuvant chemotherapy combined with immunotherapy and adjuvant immunotherapy after surgery to consolidate the curative effect can increase the pathological complete remission (pCR) rate to more than 60%. , and reduce the risk of distant deterioration or recurrence by nearly 40%, which is a major progress in breast cancer treatment.


Be brave! Active treatment of early triple negative breast cancer, towards a new life

Don’t be too scared to find out you have triple negative breast cancer! It is common in breast cancer clinics for many cancer patients to search the Internet nervously after learning that they have triple-negative breast cancer. After seeing negative terms such as high malignancy and poor prognosis, they feel hopeless and want to give up.

However, the two doctors urged cancer patients not to be discouraged. In the early stage or in the advanced stage, the treatment of triple-negative breast cancer has made significant progress in recent years.

Coupled with the high-quality medical environment in China, patients can seek the assistance of professional doctors nearby to consult the possibility of using immunotherapy. As long as they actively cooperate with the doctor’s advice, they have the opportunity Pursue better therapeutic effects and move towards a new life.



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